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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A3
All Species:
4.55
Human Site:
S376
Identified Species:
9.09
UniProt:
Q01959
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01959
NP_001035.1
620
68495
S376
G
Y
M
A
Q
K
H
S
V
P
I
G
D
V
A
Chimpanzee
Pan troglodytes
XP_001175202
689
74825
S376
G
Y
M
A
Q
K
H
S
V
P
I
G
D
V
A
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
N391
G
Y
M
A
E
M
R
N
E
D
V
S
E
V
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61327
619
68787
N375
G
Y
M
A
Q
K
H
N
V
P
I
R
D
V
A
Rat
Rattus norvegicus
P23977
619
68728
N375
G
Y
M
A
Q
K
H
N
V
P
I
R
D
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
K621
G
Y
M
A
H
E
H
K
V
K
I
E
D
V
A
Chicken
Gallus gallus
NP_990047
635
71560
K391
G
Y
M
A
H
E
H
K
V
K
I
E
D
V
A
Frog
Xenopus laevis
A7Y2X0
790
87434
N525
G
F
M
A
H
I
L
N
V
D
I
E
K
V
A
Zebra Danio
Brachydanio rerio
NP_571830
629
70143
N385
G
Y
M
S
Q
K
H
N
V
A
L
D
K
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
K383
G
Y
M
A
Y
V
Q
K
T
S
I
D
K
V
G
Honey Bee
Apis mellifera
NP_001139210
643
71921
G360
G
Y
M
A
R
A
S
G
K
S
I
Q
D
V
A
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
G369
G
Y
M
S
C
K
S
G
K
P
I
E
A
V
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.5
47.9
N.A.
N.A.
93.5
93.2
N.A.
50
67
35.8
78
N.A.
48.5
51.7
45.4
N.A.
Protein Similarity:
100
79.9
66.8
N.A.
N.A.
96.4
96.2
N.A.
59.4
80.4
52.6
86.4
N.A.
68
68.2
62.9
N.A.
P-Site Identity:
100
100
40
N.A.
N.A.
86.6
86.6
N.A.
66.6
66.6
46.6
60
N.A.
40
53.3
53.3
N.A.
P-Site Similarity:
100
100
66.6
N.A.
N.A.
93.3
93.3
N.A.
73.3
73.3
60
80
N.A.
40
60
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
84
0
9
0
0
0
9
0
0
9
0
92
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
17
0
17
59
0
0
% D
% Glu:
0
0
0
0
9
17
0
0
9
0
0
34
9
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
100
0
0
0
0
0
0
17
0
0
0
17
0
0
9
% G
% His:
0
0
0
0
25
0
59
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
0
84
0
0
0
0
% I
% Lys:
0
0
0
0
0
50
0
25
17
17
0
0
25
0
0
% K
% Leu:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% L
% Met:
0
0
100
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
42
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
42
0
0
0
0
0
% P
% Gln:
0
0
0
0
42
0
9
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
9
0
9
0
0
0
0
17
0
0
0
% R
% Ser:
0
0
0
17
0
0
17
17
0
17
0
9
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
9
0
0
67
0
9
0
0
100
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
92
0
0
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _